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 Speaker: Dr. Dean Myles, Director, Neutron Scattering Sciences Division and Center for Structural Molecular Biology, Oak Ridge National Laboratory USA.
Date: 2009-06-09
Time: 11:00
Place: Lecture hall B in the Chemistry building, Getingevägen 60, Lund
Abstract: Neutron scattering and diffraction provide information on biological processes on time and length scales that span from the atomic to the cellular levels of detail. Applications extend from the location of individual hydrogen atoms in enzymes through to the analysis of protein complexes and assemblies in solution and in membrane associated states. Neutron spectroscopy extends this view to the dynamic world, providing pico-second to micro-second information on biological molecules in motion. The next generation of Spallation Neutron Sources, currently under construction in the US and Japan, will deliver further 10-50-fold gains in performance and will greatly extend the range and scale of biological systems that can be studied by these sophisticated techniques. The Spallation Neutron Source (SNS) at Oak Ridge National Laboratory, completed in 2006, uses an accelerator to produce the most intense beams of pulsed neutrons in the world. The facility is now well on its way toward achieving its design performance goal of 1.4 MW and offers unprecedented opportunities for biological research. We will describe past, present and future applications of neutron scattering in the health and life sciences, focusing upon the unique information that can be provided on the structure and dynamics of complex biological structures, interfaces and assemblies.
Download: Dean Myles presentation: Myles.pdf |
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Speaker: Prof. Per Persson, Department of Chemistry, Umeå University.
Date: 2009-06-02
Time: 11:00
Place: Blå Hallen, Ecology building, Sölvegatan 37 Lund
Abstract: The reactivity, mobility and availability of naturally occurring chemicals and anthropogenic contaminants in the environment are largely influenced by chemical speciation, i.e. molecular structures, elemental compositions, and redox states. Chemical speciation is controlled by processes that are inherent to heterogeneous environmental systems, and these processes include reactions at solid-liquid interfaces. With recent advances in spectroscopic methods, it is now possible to probe several of these processes under in-situ conditions. Applications of synchrotron-based X-ray absorption and infrared spectroscopic methods will be reviewed. Focus will be on the structure of metal species in aquatic and terrestrial environments, and on processes occurring at the interfaces between water solutions and environmental particles. The potential of spatially resolved spectroscopic techniques will also be discussed.
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Speaker: Prof. Dr. Peter Fratzl, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany. Date: 2009-03-06 Time: 11:00 Place: Lecture Hall B, Chemistry Department, Lund University, Lund. Abstract: Biological materials, such as bone, wood, tooth, arthropod cuticle or mollusc shells, are hierarchically structured and, thus, inhomogeneous at many length scales. Scanning and tomographic imaging using micro-focus synchrotron radiation or neutrons are ideal tools for obtaining structural information from the molecular to macroscopic length scales. Recent studies on nano-scale deformation mechanisms in tendon, bone and antler will be reviewed. Moreover, scanning x-ray imaging of bone or tooth may also reveal structural details relevant for medical applications. Download: Fratzl's presentation:
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 Speaker: Prof. Dirk Dubbers, Physikalisches Institut der Universität Heidelberg, Germany
Date: 2009-02-12
Time: 15:15
Place: Lecture Hall B, Physics Department, Lund University, Lund.
Abstract: Today most of particle physics is done at the high-energy frontier. But if one wants to look for phenomena far beyond the present Standard Model of particle physics, experiments at lowest energies and highest precision are the best choice. We shall discuss a number of ongoing experiments at the low-energy frontier of neutron particle physics. |
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 Speaker: Giuseppe Zaccai, Institut Laue Langevin, Grenoble, France
Date: 2008-12-05
Place: Biology Lecture Hall, Biology Building, LU Sölvegatan 35, Lund
Abstract: Since the importance of molecular structure and dynamics for the understanding of biological activity was established decades ago, there has not appeared a single biophysical method that on its own would the information that is needed: the mean structural organization and motions around it of the atoms in these molecules, in their cellular environment, and how they change during their functional interactions. Complementarity should be the operational keyword when experimental methods in molecular biophysics are discussed. Each method, with its strengths and weaknesses, provides partial information which not accessible by others; the deepest understanding is achieved by combining all the available information. By using examples of recent work on macromolecular assemblies, membranes and in-situ studies in live cells, I shall discuss the information that can be obtained from electron microscopy, X-ray and neutron scattering and NMR, and discuss perspective developments in these methods.
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